Acetyl chloride

Acetyl chloride is a colorless, fuming liquid with a pungent, sharp odor and high volatility; it has a boiling point of 51–52 °C and a melting point of –112 °C. It is classified as a reactive acyl halide and serves primarily as a versatile acylating agent in organic synthesis. Its principal industrial use is as a key intermediate in the production of acetic anhydride, acetates (e.g., cellulose acetate), pharmaceuticals (e.g., aspirin precursors), agrochemicals, dyes, and peroxides. It is widely employed in fine chemical manufacturing for introducing acetyl groups into alcohols, amines, and other nucleophiles across pharmaceuticals, polymers, and specialty coatings.

Acetyl Chloride is a very useful synthetic intermediate. It is a derivative of acetic acid, a weak acid, used as a reagent in numerous industrial processes. It is a chemical for acetylation in the synthesis or derivatization of organic compounds.
It appears as colorless fuming liquid with a strong odor and eye irritation effect. The relative density of 1.1051 (20 ° C), the melting point of-112 ° C, the boiling point of 51-52 ° C and the flash point is 4.4 ° C (closed dish). In the wet air, it can slowly undergo decomposition and give white smoke. When coming across water, it can be violently hydrolyzed into acetic acid and hydrogen chloride, and thus should be sealed for storage. It is miscible with benzene, acetone, chloroform, ether, glacial acetic acid and petroleum ether. Liquid is heavier than water with the vapor being heavier than air. Its chemical nature is lively. It can have metathesis reaction with many compounds. Acetyl chloride can bind to the thiol group in the protein, and therefore being toxic to humans. It is an important kind of acetylation agents with its acylation capability being stronger than acetic anhydride. It is widely used in organic synthesis, being also the catalyst for the chlorination of carboxylic acids. It is manufactured through the mixing of glacial acetic acid and phosphorus trichloride in cold condition with further heating, followed by dehydrochloration distillation.

This chemical is included in Fine Chemicals. See more about what is Acetyl chloride and Acetyl chloride SDS information.

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