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China and India are the leading exporters of p-Toluenesulfonyl Isocyanate (CAS 4083-64-1), accounting for the majority of global shipments, while the United States, Germany, and Japan represent the largest importing markets. Import volumes into the U.S. and EU have remained relatively stable since 2022, with modest growth observed in Southeast Asia, coinciding with moderate upward pressure on p-Toluenesulfonyl Isocyanate prices.
p-Toluenesulfonyl isocyanate is a colorless to pale yellow liquid with a pungent, acrid odor and moderate volatility; it typically solidifies below 25 °C (melting point ≈ 24–26 °C) and decomposes before boiling. It is an aromatic organic compound classified as a sulfonyl isocyanate and functions primarily as a specialty chemical intermediate. Its principal use is in the synthesis of N-protected amines—particularly via selective reaction with primary and secondary amines to form stable sulfonamide derivatives—serving as a key reagent in multistep organic syntheses. It is widely employed in pharmaceutical manufacturing for peptide coupling and protecting-group strategies, and finds application in the production of agrochemicals, dyes, and functional polymers.
p-Toluenesulfonyl isocyanate is a reagent used to prepare acetylated syn-1,2-diols,1 oxazolidin-2-ones,2 2,3-diamino acids,3 and N-tosylcarbonamides.4
clear liquid
This chemical is included in Fine Chemicals. See more about what is P-Toluenesulfonyl Isocyanate and P-Toluenesulfonyl Isocyanate SDS information.
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