Diethyl Sulfate

Diethyl sulfate is a colorless to pale yellow, oily liquid with a faint ethereal odor and moderate volatility; it has a boiling point of approximately 208 °C and solidifies below −25 °C. It is classified as an organosulfate ester and a potent alkylating agent. Industrially, it serves primarily as a reagent for ethylation in organic synthesis, especially in the production of pharmaceuticals, dyes, and agrochemical intermediates. Its main applications include the manufacture of cationic surfactants, textile auxiliaries, and certain alkaloid derivatives used in medicinal chemistry. It is also employed in the synthesis of ethylated heterocycles and quaternary ammonium compounds for specialty chemical formulations.

The primary use of diethyl sulfate is as a chemical intermediate (ethylating agent) in synthesis of ethyl derivatives of phenols, amines, and thiols; as an accelerator in the sulfation of ethylene; and in some sulfonation processes. It is used to manufacture dyes, pigments, carbonless paper, and textiles. It is an intermediate in the indirect hydration (strong acid) process for the preparation of synthetic ethanol from ethylene. Smaller quantities are used in household products, cosmetics, agricultural chemicals, pharmaceuticals, and laboratory reagents (IARC 1992, 1999, HSDB 2009). In 1966, it was used as a mutagen to create the Luther variety of barley (IARC 1974).
Diethyl sulfate is a colorless, oily liquid with a faint peppermint- like odor, which darkens with age (Budavari, 1996). It is miscible with alcohol and ether (O'Neil, 2006). At higher temperatures, DES rapidly decomposes into monoethyl sulfate and alcohol (NTP, 2011).

This chemical is included in Fine Chemicals. See more about what is Diethyl Sulfate and Diethyl Sulfate SDS information.

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