Formamide

Formamide is a clear, odorless, hygroscopic liquid at room temperature with a high boiling point (210 °C) and low volatility. It is a polar, amide-functionalized organic chemical classified as a primary amide and widely used as a versatile solvent and synthetic intermediate. Its strong hydrogen-bonding capacity and thermal stability make it valuable in the synthesis of pharmaceuticals, agrochemicals, and heterocyclic compounds—including purine and pyrimidine derivatives. Formamide serves as a key precursor in the production of formic acid, hydrogen cyanide, and various dyes, while also finding application as a solvent in polymer processing, electronics manufacturing, and specialty coatings.

It can be used as the raw material for synthesizing imidazole, pyrimidine, 1, 3, 5-triazine, caffeine as well as the solvents for making spinning of acrylonitrile copolymer and plastic anti-static coating, etc. Formamide has active reactive and special dissolving capability. It can be used as the raw material for organic synthesis, paper processing agents, softening agent of fiber industry and animal glue as well as being used as the analytical reagent for measuring the amino acid content of rice. In the field of organic synthesis, it has most application in medicine as well as a lot of applications in other fields such as pesticides, dyes, pigments, fragrances and additives. It is also a kind of excellent organic solvent and is mainly applied to the spinning of acrylonitrile copolymers and ion exchange resins and plastics antistatic coating or conductive coating. In addition, it can also be used for separating chlorosilane and purifying grease. Formamide can have various kinds of reactions, in addition to have its three hydrogen atoms participate in the reaction, can also be subject to dehydration, CO removal, the introduction of an amino group, an acyl group and cyclization reaction. Take cyclization as an example, diethyl malonate can have cyclization reaction with formamide to generate the intermediate of vitamin B4, the 4, 6-dihydroxypyrimidine. O-aminobenzoic acid can have cyclization reaction with formamide to generate the quinazolinone-4 which is the intermediate for the synthesis of antiarrhythmic drug phenantrolihne. 3--amino-4-ethoxycarbonyl-pyrazole can have cyclization reaction with formamide to generate the inhibitor of the xanthine oxidase, allopurinol. EDTA can have cyclization reaction with formamide to give anti-cancer drugs ethylenediamine. Methyl ethyl methoxymalonate can have cyclization reaction with formamide to generate the intermediate of sulfonamide drug, 5-methoxy-4, 6-dihydroxy pyrimidine disodium.It can be used as analytical reagents, solvents and softening agents as well as being used in organic synthesis.It can be applied to medicine and pesticide industry.

This chemical is included in Fine Chemicals. See more about what is Formamide and Formamide SDS information.

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